Remove unwanted variation using control genes

Adapted from RUVSeq (https://doi.org/10.1038%2Fnbt.2931)

Usage

enRUVg(object, log = TRUE, k = 1, tolerance = 1e-08, control.idx, drop = 1)

object: A counts matrix.
log: Whether to perform log2-transformation with 1 offset on data matrix, default: TRUE.
k: The number of factors of unwanted variation to be estimated from the data.
tolerance: Tolerance in the selection of the number of positive singular values, i.e., a singular value must be larger than tolerance to be considered positive.
control.idx: ID of control genes.
drop: The number of singular values to drop in the estimation of unwanted variation, default drop the first singular value that represent the difference between enrichment and input

list contain a matrix of unwanted factors (W) and corrected counts matrix (normalizedCounts).